August 2023 – Page 3 – MES Engineer

Creating and binding self-signed SSL Certificates in IIS

August 20, 2023 MES ENGINEER

To create and bind a self-signed SSL certificate with PowerShell and IIS, you can follow these steps: Make sure to replace “yourdomain.com” with your actual domain name. The certificate will be stored in the “My” certificate store. Replace “password” with your desired password, and “C:\path\to\certificate.pfx” with the desired path and filename for the exported certificate. Your self-signed SSL certificate is now created and bound to the specified website in IIS. Please note that self-signed certificates are not trusted by default in web browsers and may trigger security warnings when accessed…

ALCOA+

August 20, 2023 MES ENGINEER

ALCOA+ is a quality management framework used in various industries, particularly in healthcare and clinical research. It is an extension of the original ALCOA principles, which are a set of guidelines to ensure data integrity in regulated environments. ALCOA stands for: The “+” in ALCOA+ represents additional principles that enhance data integrity. These principles include: Adhering to the ALCOA+ framework helps organizations ensure the reliability and trustworthiness of their data by maintaining accurate, complete, and unalterable records. By following these principles, organizations can improve data quality, transparency, and compliance with…

Basic Cyber Security Principles to Protect MES Systems

August 20, 2023 MES ENGINEER

Cybersecurity is crucial for protecting Manufacturing Execution Systems (MES) and ensuring the integrity, availability, and confidentiality of data. Here are some basic fundamentals to consider for enhancing cybersecurity in MES systems: Remember, cybersecurity is an ongoing process. Regularly reassess and update your security measures to adapt to the evolving threat landscape.

Beyond Compare

August 20, 2023 MES ENGINEER

I have been using Beyond Compare for over a decade now, and I can confidently say that it has been an indispensable tool in my daily workflow. This exceptional file and folder comparison software has consistently provided me with accurate and reliable results, making it an essential part of my professional toolkit. One of the standout qualities of Beyond Compare is its consistency. Over the years, this tool has continuously delivered outstanding performance, ensuring that I can rely on it for all my comparison and synchronization needs. Its stability and…

Fiddler Web Debugger

August 20, 2023 MES ENGINEER

I have been using Fiddler Web Debugger for over a decade, and I must say, it has been an essential tool in my web development arsenal. With its extensive range of features and user-friendly interface, Fiddler has consistently proven its worth, allowing me to debug and analyze web traffic effortlessly. One of the standout features of Fiddler is its robust interception capabilities. Being able to intercept and inspect HTTP and HTTPs traffic has been invaluable in identifying and troubleshooting issues in real-time. Whether it’s analyzing API requests, monitoring network activity,…

Basics of cell therapy

August 20, 2023 MES ENGINEER

Cell therapy, also known as cellular therapy or regenerative medicine, is a form of treatment that utilizes living cells to help repair, replace, or regenerate damaged or diseased tissues or organs in the body. The primary goal of cell therapy is to restore normal functioning and improve the overall health and well-being of patients. Here is a general overview of how cell therapy works: It is important to note that cell therapy is a complex field, and the specific mechanisms and approaches may differ depending on the type of cells…

SP_Blitz

August 20, 2023 MES ENGINEER

Long-Term admiration for SP_Blitz Having used SP_Blitz for several years now, I am thrilled to share my positive experience with this exceptional SQL Server tool. SP_Blitz has become an indispensable companion in my daily work as a SQL Server DBA. From the moment I first started using SP_Blitz, I was impressed by its ability to thoroughly analyze and diagnose my SQL Server instances. After all this time, it continues to amaze me with its comprehensive and insightful recommendations. One of the standout features of SP_Blitz is its ability to adapt…

Ola Hallengren’s SQL Maintenance: A Reliable Solution for Database Optimization

August 20, 2023 MES ENGINEER

Introduction In the fast-paced realm of database management, ensuring optimal performance and stability is crucial. Ola Hallengren’s SQL Maintenance tool has been a trusted solution in the industry for several years, aiding countless organizations in their quest for efficient database maintenance. With its comprehensive features and user-friendly interface, Ola Hallengren’s solution has proven to be a valuable asset for SQL Server administrators worldwide. Key Features 1. Database Integrity Checks The SQL Maintenance tool provides a robust system for regularly checking the integrity of your SQL databases. With customizable scheduling options,…

Common Biotech Buzzwords and Descriptions

August 20, 2023 MES ENGINEER

Buzzword Description Gene Editing The process of modifying an organism’s genetic material to achieve desired traits or characteristics. It involves targeted changes to the DNA sequence, such as adding, deleting, or modifying specific genes. CRISPR A revolutionary gene-editing technology that allows scientists to precisely modify an organism’s DNA. CRISPR-Cas9, the most widely used CRISPR system, uses a molecular tool to guide the editing process by directing the Cas9 enzyme to cut the DNA at specific locations, enabling the addition, removal, or modification of genetic material. Biopharmaceuticals Medicinal products derived from…

The Purdue Model of Security for Manufacturing: Safeguarding Industrial Control Systems

August 20, 2023 MES ENGINEER

In an increasingly interconnected world, securing industrial control systems (ICS) has become a critical concern for manufacturing companies. One widely recognized approach to ICS security is the Purdue Model, also known as the Purdue Enterprise Reference Architecture. Developed by the Purdue University’s Center for Education and Research in Information Assurance and Security (CERIAS), this model provides a framework for organizing and securing control systems in manufacturing environments. Understanding the Purdue Model The Purdue Model is based on the concept of hierarchical levels, each responsible for specific functions and security controls…